A new approach
“The Bredesen Protocol™ provides a comprehensive personalized program designed to improve cognition and reverse the cognitive decline of subjective cognitive impairment SCI, mild cognitive impairment MCI, and early Alzheimer’s disease. Continued research and testing by Dr Bredesen began by evolving MEND into The Bredesen Protocol™, which has identified new and previously unrecognized causes of Alzheimer’s disease.
The Bredesen Protocol addresses the cause of each condition in a comprehensive, personalised and programmatic way that leads to improved outcomes. Each programme is repeatedly optimised over time, to ensure sustained improvement”
The Bredesen Protocol is relatively new. The science behind it and Dr Bredesen’s case histories make a very strong case for the validity of this approach. The Protocol is designed to help halt and reverse cognitive decline and is found to be most successful in people in the earlier stages of cognitive decline.
The outcomes in people with more advanced cognitive decline are less certain, though improvements may be seen even in these cases. The approach is centred around diet and lifestyle management and will almost certainly include the use of supplements. As Functional Medicine practitioners we are delighted this new approach for the management of cognitive decline is available for patients, where no other active intervention to date exists. However, it is a new protocol, therefore there is no long-term data to refer to as yet.
Whilst we cannot guarantee outcomes, we nonetheless offer our full dedication, support and specific knowledge in getting you there.
For more information visit Dr Bredesen’s website or see the following research publications:
The Berendsens protocol – Fees and costs
Initial consultation (90-120 minutes)
Includes initial consultation, first ReCode report, viewing of relevant specialist correspondence, a letter to the GP where required, phlebotomy during first consultation where required
Follow-up appointments (60 minutes)
Includes consultation, follow-up ReCode reports
Uploading results and running ReCode report ahead of consultation
Letters to GP, other healthcare professionals, depending on complexity
Emails and Text Messages
We encourage patients to contact us by email or text for quick queries (e.g. request for repeat prescription). We do not charge extra for these. However, more elaborate updates and multiple queries are not suitably answered by email. In this case please book a follow-up appointment.
The typical number of follow-up appointments with Dr Mo over a 12-month period is 4, but may be more or less, according to individual need.
Fortnightly consultations for first 2 months
(4 sessions) – 30 minutes
After the first 2 months, follow-ups may be every 4-6 weeks, according to patients’ needs
(30 min or 60 min)
£125/30 min (£250 p/h pro rata)
We would prefer if the first consultation were face-to face, whereas follow-ups may be carried out remotely by phone or skype.
Prices do not include tests and investigations
Please note you will also need to register with ReCode ($75/month for 12 months)
Please contact https://www.drbredesen.com/participants indicating Dr Daniela Mo as your chosen provider.
More about the Berendsens protocol
The typical journey of a patient with early signs of cognitive decline starts with mild or inconsistent ‘forgetfulness’, or with subtle changes in the ability to perform certain tasks. These initial signs may be dismissed as ‘getting older’ or ‘due to stress’, but overtime they gradually accumulate. Months or years may pass before a patient consults a doctor, often because of a perceived notion that there is nothing that can be done about it. The standard management will include some cognitive testing, imaging of the brain, and, in the latter stages of the condition, supportive interventions, and medication to manage some of the symptoms. The standard approach does not currently offer a cure, thereby contributing to the fear of inexorable decline.
The Bredesen approach strives to identify and correct the underlying causes of cognitive decline, especially during those early stages, where the window of therapeutic opportunity is greatest.
In order to optimise outcomes, patients are invited to see both Dr Daniela Mo and Dietitian Lynda Mallinson.
Prior to the first consultation you will be invited to return the completed intake questionnaires.
The first consultation will be the longest, please allow at least 2 hours. During this consultation we shall take a detailed medical and dietary history, carry out appropriate cognitive tests, and make an initial plan.
The Bredesen Protocol requires a standard set of blood tests and imaging, which need to be done in order to identify the type of Alzheimer’s, according to Dr Bredesen’s classification. Ideally these would be carried out before the first consultation (please see below for details). Specific recommendations will be made based on those results. Pre-existing results (up to 6 months) may be used in this context, to avoid unnecessary duplication.
Other tests may be indicated depending on a patient’s specific history and presentation, if it is thought to add to our understanding and management.
The programme is designed to be carried out approximately over the course of one year.
After the initial consultation, Dr Mo will typically require another 3-4 consultations, whilst Lynda will typically need another 10-12 consultations, of which 4 in the first 2 months. This is designed to give optimal support especially at the beginning of the programme where issues are most likely to arise. In our experience, patients and their carers find this support invaluable and necessary
Please see above.
This will vary from patient to patient, however as a rule of thumb you may need to spend between £1000 and £1500 on initial blood tests ( we use The Doctors Laboratory -TDL) and about £700 for an MRI scan (we currently refer to Oryon-The London Imaging Centre) plus a £ 100 fee for interpretation (calculation of hippocampal percentile volumetrics). MRI scans are not mandatory to start the Bredesen Protocol but may offer important information.
The initial blood tests are the most expensive, as they are more detailed. A standard, comprehensive baseline panel costs £1052 and may be completed prior to the first consultation, though extra tests may be recommended after the first visit, depending on your medical history and circumstances. Please inform us if you have already had genetic tests (APOE and MTHFR), as these will not be requested in the baseline panel, thereby reducing its cost.
Subsequent blood panels may be less expensive as some of the initial tests will not need to be repeated. Repeat blood tests on average cost £ 500-600 and may be required 2-3 times in the course of the year. These prices are based on an arrangement with The Doctors Laboratory who have designed discounted panels specifically for our patients on the Bredesen Protocol. You are free to have tests done via other providers; however, the price may differ from the ones we quote here.
The blood draw can be done anywhere in the country, and the samples sent to TDL. Similarly, the MRI scan can be done anywhere, however it should ideally be from a provider that can offer not only descriptive reports of the brain, but also provide suitable images for the estimation of “hippocampal percentile volumetrics”. Not all providers offer this. Please check before booking or ask us to clarify with the provider.
It is quite difficult to answer this question with any degree of accuracy. The need for supplements will depend on the result of the tests. Some people need more than others. Again, as a very generic rule of thumb, you may need to spend £150 a month on supplements. Some people will need to spend much less, some people more.
You will continue taking your regular medication, as prescribed by your GP. Generally speaking, supplements will not interfere with your medications, but if there is any risk of adverse effects or interactions, we will advise you.
As you follow the plan, the need or indication for medication may change. We will discuss this with you in detail as the need arises and will liaise with your GP accordingly.